Sankaranarayanan, Sethu: search on Z-Library

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1

Effects of sub-chronic donepezil on brain Abeta and cognition in a mouse model of Alzheimer’s disease

Easton, Amy, Sankaranarayanan, Sethu, Tanghe, An, Terwel, Dick, Lin, Alan X., Hoque, Nina, Bourin, Clotilde, Gu, Huidong, Ahlijanian, Michael, Bristow, Linda

Journal:

Psychopharmacology

Year:

2013

Language:

english

File:

PDF, 386 KB

english, 2013

2

Novel human CSF tau-fragment and pTau assays for distinguishing Alzheimer's from control subjects

Sethu Sankaranarayanan, Jere Meredith, Valerie Guss, Alan Xu-Lin, Holly Soares, Kaj Blennow, Charles Albright, Michael Ahlijanian

Journal:

Alzheimer's & Dementia

Year:

2012

Language:

english

File:

PDF, 59 KB

english, 2012

3

Nonclinical Development of ANX005: A Humanized Anti-C1q Antibody for Treatment of Autoimmune and Neurodegenerative Diseases

Lansita, Janice A., Mease, Kirsten M., Qiu, Haiyan, Yednock, Ted, Sankaranarayanan, Sethu, Kramer, Susan

Journal:

International Journal of Toxicology

Year:

2017

Language:

english

File:

PDF, 1.53 MB

english, 2017

4

Macrocyclic Inhibitors of β-Secretase: Functional Activity in an Animal Model.

Stachel, Shawn J., Coburn, Craig A., Sankaranarayanan, Sethu, Price, Eric A., Wu, Guoxin, Crouthamel, Michelle, Pietrak, Beth L., Huang, Qian, Lineberger, Janet, Espeseth, Amy S., Jin, Lixia, Ellis, J

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 6 KB

english, 2006

5

Subretinal macrophages produce classical complement activator C1q leading to the progression of focal retinal degeneration

Jiao, Haihan, Rutar, Matt, Fernando, Nilisha, Yednock, Ted, Sankaranarayanan, Sethu, Aggio-Bruce, Riemke, Provis, Jan, Natoli, Riccardo

Journal:

Molecular Neurodegeneration

Year:

2018

Language:

english

File:

PDF, 8.95 MB

english, 2018

6

Strategies toward improving the brain penetration of macrocyclic tertiary carbinamine BACE-1 inhibitors

Keith P. Moore, Hong Zhu, Hemaka A. Rajapakse, Georgia B. McGaughey, Dennis Colussi, Eric A. Price, Sethu Sankaranarayanan, Adam J. Simon, Nicole T. Pudvah, Jerome H. Hochman, Timothy Allison, Sanjeev

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 342 KB

english, 2007

7

O3-02-06: Elevated cerebrospinal fluid BACE1 activity in incipient Alzheimer's disease

Henrik Zetterberg, Ulf Andreasson, Oskar Hansson, Guoxin Wu, Sethu Sankaranarayanan, Malin E. Andersson, Peder Buchhave, Elisabet Londos, Robert M. Umek, Lennart Minthon, Adam J. Simon, Kaj Blennow

Journal:

Alzheimer's & Dementia

Year:

2008

Language:

english

File:

PDF, 57 KB

english, 2008

8

The Classical Complement Pathway Mediates Microglia-Dependent Remodeling of Spinal Motor Circuits during Development and in SMA

Vukojicic, Aleksandra, Delestrée, Nicolas, Fletcher, Emily V., Pagiazitis, John G., Sankaranarayanan, Sethu, Yednock, Ted A., Barres, Ben A., Mentis, George Z.

Journal:

Year:

2019

File:

PDF, 5.32 MB

2019

9

Viable mouse gene ablations that robustly alter brain Aβ levels are rare

Jeremy H Toyn, Xu-Alan Lin, Mark W Thompson, Valerie Guss, Jere E Meredith, Sethu Sankaranarayanan, Nestor Barrezueta, John Corradi, Antara Majumdar, Daniel L Small, Melissa Hansard, Thomas Lanthorn,

Journal:

BMC Neuroscience

Year:

2010

Language:

english

File:

PDF, 1.24 MB

english, 2010

10

Characterization of plasma β-secretase (BACE1) activity and soluble amyloid precursor proteins as potential biomarkers for Alzheimer's disease

Guoxin Wu, Sethu Sankaranarayanan, Jacky Wong, Katherine Tugusheva, Maria S. Michener, Xiaoping Shi, Jacquelynn J. Cook, Adam J. Simon, Mary J. Savage

Journal:

Journal of Neuroscience Research

Year:

2012

Language:

english

File:

PDF, 814 KB

english, 2012

11

P2-069: Nonhuman primate model for prediction of human Aβ effects. Targeting γ-secretase: Effects of enzyme inhibition vs. modulation of cleavage specificity on CSF and plasma Aβ in conscious rhesus monkeys

Maria S. Michener, Marie A. Holahan, David B. Gilberto, Gary R. Sitko, Mark S. Shearman, Tim Harrison, Huw Lewis, Sethu Sankaranarayanan, Michelle Crouthamel, Guoxin Wu, Beth L. Pietrak, Adam J. Simon

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 162 KB

english, 2006

12

Subretinal macrophages produce classical complement activator C1q leading to the progression of focal retinal degeneration

Jiao, Haihan, Rutar, Matt, Fernando, Nilisha, Yednock, Ted, Sankaranarayanan, Sethu, Aggio-Bruce, Riemke, Provis, Jan, Natoli, Riccardo

Journal:

Molecular Neurodegeneration

Year:

2018

File:

PDF, 8.95 MB

2018

13

P2-137 Secretase inhibitors reduce amyloid production in primary neurons from novel MWP HUAPP KI mice

Sethu Sankaranarayanan, Lin Chen, Guoxin Wu, Ming-Chih Crouthamel, Eric A. Price, Richard Z. Chen, Thomas F. Vogt, Shawn Stachel, Craig Coburn, Daria J. Hazuda, Adam J. Simon

Journal:

Neurobiology of Aging

Year:

2004

Language:

english

File:

PDF, 160 KB

english, 2004

14

Efficacy and safety of systemic versus intracerebroventricular delivery of a β-secretase (BACE1) small molecule inhibitor in a mouse model of Alzheimer's disease

Thakker, Deepak, Sankaranarayanan, Sethu, Weatherspoon, Marcy, Harrison, Jonathan, Pierdomenico, Maria, Heisel, Jennifer, Nix, Bradley, Thompson, Lorin, Haskell, Roy, Grace, James, Taylor, Sarah, Albr

Journal:

Alzheimer's & Dementia

Year:

2011

Language:

english

File:

PDF, 214 KB

english, 2011

15

Characterization of Novel CSF Tau and ptau Biomarkers for Alzheimer’s Disease

Meredith Jr., Jere E., Sankaranarayanan, Sethu, Guss, Valerie, Lanzetti, Anthony J., Berisha, Flora, Neely, Robert J., Slemmon, J. Randall, Portelius, Erik, Zetterberg, Henrik, Blennow, Kaj, Soares, H

Journal:

Year:

2013

Language:

english

File:

PDF, 1.46 MB

english, 2013

16

P4-324

Sankaranarayanan, Sethu, Price, Eric, Crouthamel, Michelle, Wu, Guoxin, Ellis, Joan, Jin, Lixia, Stachel, Shawn, Graham, Samuel, Vacca, Joeseph, Coburn, Craig, Simon, Adam

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 60 KB

english, 2006

17

Elevated Cerebrospinal Fluid BACE1 Activity in Incipient Alzheimer Disease

Zetterberg, Henrik, Andreasson, Ulf, Hansson, Oskar, Wu, Guoxin, Sankaranarayanan, Sethu, Andersson, Malin E., Buchhave, Peder, Londos, Elisabet, Umek, Robert M., Minthon, Lennart, Simon, Adam J., Ble

Journal:

Archives of Neurology

Year:

2008

Language:

english

File:

PDF, 133 KB

english, 2008

18

C1q-targeted inhibition of the classical complement pathway prevents injury in a novel mouse model of acute motor axonal neuropathy

McGonigal, Rhona, Cunningham, Madeleine E., Yao, Denggao, Barrie, Jennifer A., Sankaranarayanan, Sethu, Fewou, Simon N., Furukawa, Koichi, Yednock, Ted A., Willison, Hugh J.

Journal:

Acta Neuropathologica Communications

Year:

2016

Language:

english

File:

PDF, 2.84 MB

english, 2016

19

P2-066 A genetically engineered mouse model with an enhanced beta-secretase substrate exhibits increased amyloid generation

Adam J. Simon, Lin Chen, Eric A. Price, Min Xu, Adam Lucka, Mei Tang, Elizabeth Chen, Amy S. Espeseth, Mohinder Sardana, Xiao-Ping Shi, Michael J. Marino, Guoxin Wu, Sethu Sankaranarayanan, Daria J. H

Journal:

Neurobiology of Aging

Year:

2004

Language:

english

File:

PDF, 157 KB

english, 2004

20

Probing Conformational Dynamics of Tau Protein by Hydrogen/Deuterium Exchange Mass Spectrometry

Huang, Richard Y.-C., Iacob, Roxana E., Sankaranarayanan, Sethu, Yang, Ling, Ahlijanian, Michael, Tao, Li, Tymiak, Adrienne A., Chen, Guodong

Journal:

Journal of the American Society for Mass Spectrometry

Year:

2017

Language:

english

File:

PDF, 1.51 MB

english, 2017

21

Discovery of Isonicotinamide Derived β-Secretase Inhibitors: In Vivo Reduction of β-Amyloid

Ellis, Joan, Stanton, Matthew G., Stauffer, Shaun R., Gregro, Alison R., Steinbeiser, Melissa, Nantermet, Philippe, Sankaranarayanan, Sethu, Price, Eric A., Wu, Guoxin, Crouthamel, Ming-Chih

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 59 KB

english, 2007

22

Cisterna magna cannulated repeated CSF sampling rat model – effects of a gamma-secretase inhibitor on Aβ levels

Jennifer S. Shapiro, Mark Stiteler, Guoxin Wu, Eric A. Price, Adam J. Simon, Sethu Sankaranarayanan

Journal:

Journal of Neuroscience Methods

Year:

2012

Language:

english

File:

PDF, 1.07 MB

english, 2012

23

Decrease in age-adjusted cerebrospinal fluid β-secretase activity in Alzheimer's subjects

Guoxin Wu, Sethu Sankaranarayanan, Kate Tugusheva, Jason Kahana, Guy Seabrook, Xiao-ping Shi, Elizabeth King, Viswanath Devanarayan, Jacquelynn J. Cook, Adam J. Simon

Journal:

Clinical Biochemistry

Year:

2008

Language:

english

File:

PDF, 1.01 MB

english, 2008

24

P4-315

Henze, Darrell A., Rosenberg, Stephanie, Crouthamel, Michelle C., Sankaranarayanan, Sethu, Williamson, Toni, Richards, Pawel, Shearman, Mark S., Simon, Adam J., Seabrook, Guy R., Kinney, Gene G.

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 59 KB

english, 2006

25

Genetically Modified Mice Models for Alzheimers Disease

Sankaranarayanan, Sethu

Journal:

Current Topics in Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 206 KB

english, 2006

26

Novel tau fragments are present in human CSF

Jere Meredith, Randall Slemmon, Valerie Guss, Anthony Lanzetti, Sethu Sankaranarayanan, Holly Soares, Kaj Blennow, Charlie Albright, Michael Ahlijanian

Journal:

Alzheimer's & Dementia

Year:

2012

Language:

english

File:

PDF, 435 KB

english, 2012

27

Pharmacological applications of a novel neoepitope antibody to a modified amyloid precursor protein-derived beta-secretase product

Guoxin Wu, Sethu Sankaranarayanan, Donna L. Montgomery, Adam J. Simon, Zhiqiang An, Mary J. Savage

Journal:

Year:

2011

Language:

english

File:

PDF, 521 KB

english, 2011

28

Decrease in brain soluble amyloid precursor protein β (sAPPβ) in Alzheimer's disease cortex

Guoxin Wu, Sethu Sankaranarayanan, Sidney H.-K. Hsieh, Adam J. Simon, Mary J. Savage

Journal:

Journal of Neuroscience Research

Year:

2011

Language:

english

File:

PDF, 1.41 MB

english, 2011

29

Macrocyclic Inhibitors of β-Secretase: Functional Activity in an Animal Model

Stachel, Shawn J., Coburn, Craig A., Sankaranarayanan, Sethu, Price, Eric A., Pietrak, Beth L., Huang, Qian, Lineberger, Janet, Espeseth, Amy S., Jin, Lixia, Ellis, Joan, Holloway, M. Katharine, Munsh

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 86 KB

english, 2006

30

Protein Trafficking in Neurons || Neuronal Exocytosis

SANKARANARAYANAN, SETHU

Year:

2007

Language:

english

File:

PDF, 3.63 MB

english, 2007

31

Rapid P1 SAR of brain penetrant tertiary carbinamine derived BACE inhibitors

Hong Zhu, Mary B. Young, Philippe G. Nantermet, Samuel L. Graham, Dennis Colussi, Ming-Tain Lai, Beth Pietrak, Eric A. Price, Sethu Sankaranarayanan, Xiao-ping Shi, Katherine Tugusheva, Marie A. Holah

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 1.21 MB

english, 2010

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